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Daily. Med - DURAGESIC- fentanyl patch. Addiction, Abuse, and Misuse DURAGESIC contains fentanyl, an opioid agonist and a Schedule II controlled substance. As an opioid, DURAGESIC exposes users to the risks of addiction, abuse, and misuse . As modified- release products such as DURAGESIC deliver the opioid over an extended period of time, there is a greater risk for overdose and death due to the larger amount of fentanyl present. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed DURAGESIC and in those who obtain the drug illicitly. Addiction can occur at recommended doses and if the drug is misused or abused. Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing DURAGESIC, and monitor all patients receiving DURAGESIC for the development of these behaviors or conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol addiction or abuse) or mental illness (e. The potential for these risks should not, however, prevent the prescribing of DURAGESIC for the proper management of pain in any given patient. Patients at increased risk may be prescribed modified- release opioid formulations such as DURAGESIC, but use in such patients necessitates intensive counseling about the risks and proper use of DURAGESIC along with intensive monitoring for signs of addiction, abuse, and misuse. Abuse or misuse of DURAGESIC by placing it in the mouth, chewing it, swallowing it, or using it in ways other than indicated may cause choking, overdose, and death . Consider these risks when prescribing or dispensing DURAGESIC. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug . Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product. Life- Threatening Respiratory Depression. Serious, life- threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression from opioid use, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient's clinical status . Carbon dioxide (CO2) retention from opioid- induced respiratory depression can exacerbate the sedating effects of opioids. DURAGESIC is indicated only in opioid tolerant patients because of the risk for respiratory depression and death. While serious, life- threatening, or fatal respiratory depression can occur at any time during the use of DURAGESIC, the risk is greatest during the initiation of therapy or following a dose increase. Closely monitor patients for respiratory depression when initiating therapy with DURAGESIC. To reduce the risk of respiratory depression, proper dosing and titration of DURAGESIC are essential . Overestimating the DURAGESIC dose when converting patients from another opioid product can result in fatal overdose with the first dose. Accidental exposure to DURAGESIC, especially in children, can result in respiratory depression and death due to an overdose of fentanyl. Accidental Exposure. A considerable amount of active fentanyl remains in DURAGESIC even after use as directed. Death and other serious medical problems have occurred when children and adults were accidentally exposed to DURAGESIC. Accidental or deliberate application or ingestion by a child or adolescent will cause respiratory depression that can result in death. Placing DURAGESIC in the mouth, chewing it, swallowing it, or using it in ways other than indicated may cause choking or overdose that could result in death. Improper disposal of DURAGESIC in the trash has resulted in accidental exposures and deaths. Learn about the potential side effects of Duragesic-25 (fentanyl). Includes common and rare side. Common side effects of Duragesic-25. 25 mcg m,w,f since Jan 23, 2013. The fentanyl transdermal patch may burn your skin if you wear. Discontinue all other around-the-clock opioid drugs when initiating the fentanyl patch.Fentanyl side effects and concerns. 87.5 mcg/hour, 12 mcg/hr, 25 mcg/hr, 50 mcg/hr, 75 mcg/hr, 100 mcg/hr. I have been on the fentanyl patch for 18 yrs now. Advise patients about strict adherence to the recommended handling and disposal instructions in order to prevent accidental exposure to DURAGESIC . Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life- threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. Neonatal opioid withdrawal syndrome presents as irritability, hyperactivity and abnormal sleep pattern, high pitched cry, tremor, vomiting, diarrhea and failure to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary based on the specific opioid used, duration of use, timing and amount of last maternal use, and rate of elimination of the drug by the newborn. Interactions with Central Nervous System Depressants Hypotension, profound sedation, coma, respiratory depression, and death may result if DURAGESIC is used concomitantly with alcohol or other central nervous system (CNS) depressants (e. When considering the use of DURAGESIC in a patient taking a CNS depressant, assess the duration use of the CNS depressant and the patient's response, including the degree of tolerance that has developed to CNS depression. Additionally, evaluate the patient's use of alcohol or illicit drugs that cause CNS depression. If the decision to begin DURAGESIC is made, reduce the starting dose, monitor patients for signs of sedation and respiratory depression, and consider using a lower dose of the concomitant CNS depressant . Monitor such patients closely, particularly when initiating and titrating DURAGESIC and when DURAGESIC is given concomitantly with other drugs that depress respiration . Consider the use of alternative non- opioid analgesics in these patients if possible. Head Injuries and Increased Intracranial Pressure. Avoid use of DURAGESIC in patients who may be particularly susceptible to the intracranial effects of CO2 retention such as those with evidence of increased intracranial pressure, impaired consciousness, or coma . In addition, opioids may obscure the clinical course of patients with head injury. Monitor patients with brain tumors who may be susceptible to the intracranial effects of CO2 retention for signs of sedation and respiratory depression, particularly when initiating therapy with DURAGESIC, as DURAGESIC may reduce respiratory drive and CO2 retention can further increase intracranial pressure. Hypotensive Effects. DURAGESIC may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is an increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e. Monitor these patients for signs of hypotension after initiating or titrating the dose of DURAGESIC. Interactions with CYP3. A4 Inhibitors and Inducers Since the CYP3. A4 isoenzyme plays a major role in the metabolism of DURAGESIC, drugs that alter CYP3. A4 activity may cause changes in clearance of fentanyl which could lead to changes in fentanyl plasma concentrations. The concomitant use of DURAGESIC with a CYP3. A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil) may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. Carefully monitor patients receiving DURAGESIC and any CYP3. A4 inhibitor for signs of sedation and respiratory depression for an extended period of time, and make dosage adjustments as needed. CYP4. 50 inducers, such as rifampin, carbamazepine, and phenytoin, may induce the metabolism of fentanyl and, therefore, may cause increased clearance of the drug which could lead to a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, development of an abstinence syndrome in a patient who had developed physical dependence to fentanyl. If co- administration is necessary, caution is advised when initiating DURAGESIC treatment in patients currently taking, or discontinuing, CYP3. A4 inhibitors or inducers. Evaluate these patients at frequent intervals and consider dose adjustments until stable drug effects are achieved . A clinical pharmacology study conducted in healthy adult subjects has shown that the application of heat over the DURAGESIC system increased fentanyl exposure . Monitor patients wearing DURAGESIC systems who develop fever closely for opioid side effects and reduce the DURAGESIC dose if necessary. Warn patients to avoid strenuous exertion that leads to increased core body temperature while wearing DURAGESIC to avoid the risk of potential overdose and death. Cardiac Disease. DURAGESIC may produce bradycardia. Monitor patients with bradyarrhythmias closely for changes in heart rate, particularly when initiating therapy with DURAGESIC. Hepatic Impairment. A clinical pharmacology study with DURAGESIC in patients with cirrhosis has shown that systemic fentanyl exposure increased in these patients. Because of the long half- life of fentanyl when administered as DURAGESIC and hepatic metabolism of fentanyl, avoid use of DURAGESIC in patients with severe hepatic impairment. Insufficient information exists to make precise dosing recommendations regarding the use of DURAGESIC in patients with impaired hepatic function. Therefore, to avoid starting patients with mild to moderate hepatic impairment on too high of a dose, start with one half of the usual dosage of DURAGESIC. Durogesic DTrans 12 mcg/hr Transdermal Patch. Accidental transfer of a fentanyl patch. The risk of fentanyl patch's side effects, including breathing problems. Store fentanyl patch below 77 degrees F (25 degrees C) in its original sealed pouch. Does anyone have any experience with 25 mcg Fentanyl patches Side effects? Duragesic-25 (fentanyl transdermal patch). Fentanyl can cause side effects that may impair. Closely monitor for signs of sedation and respiratory depression, including at each dosage increase. Fentanyl (Transdermal Route) Side Effects. Drug information provided by: Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common. Decrease in the amount of urine or in the frequency of urination. Incidence not known. Bloating or swelling of the face, hands, lower legs, or feet. Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose. Cold, clammy skin. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common. Abdominal or stomach pain that was not present before treatment. Feeling anxious and restless at the same time. Incidence not known. Change or problem with discharge of semen. After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1- 8. FDA- 1. 08. 8. Portions of this document last updated: Jan. 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Do you remember what car you were driving, or how your hair looked? How old were your kids? This is an update to the 45.31.0 software for the Motorola ATRIX. This update includes several improvements to device performance. For optimal future device performance. Patch for Android browser vulnerability. The software on Motorola's upcoming Atrix 4G has already been subject to some stern (and premature) scrutiny, but here's some rather more concrete information about it, courtesy of the company's own spec page for. Patch Lead for Motorola Atrix. Phone-to-Antenna connector lead for Motorola Atrix MB860. Sad but true, eight months is the new eight years in the smartphone industry, and that measly old Atrix already has a successor. Whereas the Atrix 4. G was a major step for AT& T in terms of both Android and network strength, the Atrix 2 is less of a trailblazer. And this type of incremental update seems like the business model that Motorola is building for itself (see Droid X/X2, Droid line). But for the consumer, how can you tell when an incremental update is enough to fork over more money? And in the Atrix 2's case, is an incremental update enough to compete with some heavy hitters during this holiday season, perhaps the most exciting time for Android since its birth in 2. The Atrix 2 is a large phone, in terms of both footprint and girth. Make no mistake about it: the Atrix 2 won't have any “world's . I've used some of the biggest smartphones on the block, yet the Atrix 2 managed to surprise me. It's not necessarily bigger that say, the HTC Thunderbolt, but the size, combined with curved edges and relatively thick profile, sure make the Atrix 2 noticeable. It's thinner than the original Atrix but that's not saying much: It's still 1. Samsung's. Galaxy S II would cringe at. Another thing that you'll notice about the Atrix 2 is the less- than- top- notch build quality. The Atrix 2 is entirely too plasticky. The back cover, a rubberized sheet that prys off without much cooperation, is extremely flimsy, and even the bezel that surrounds the Atrix 2's screen feels cheap and breakable. When I first held the Atrix 2 I felt like it was a phone that I might be able to win out of a claw machine. One upside to this build quality: weight. Despite its heft, the Atrix 2 is relatively lightweight. A brick it is not. The Atrix 2's physical saving grace is the beautiful display. A 4. 3- inch q. HD screen with 9. Gorilla Glass, the Atrix 2's display is a beauty. Colors are vivid and text is crisp and sharp. And yes, you'll notice! The Atrix 2 looks much better than the Bionic and as we see with the Droid RAZR, Motorola is improving its screen technology every day. Other hardware odds and ends: the micro. SD card doesn't require battery removal to install, which is such a treat. And the rear speaker suffices but I've heard much, much better. Don't throw away your stereo. Departing from its commitment to Tegra 2, Motorola has switched its processor- of- choice to Texas Instruments, and the dual- core OMAP 4. Atrix 2 is the beautiful result of that decision. Clocked at 1 GHz, it might not be the fastest on the market, but I couldn't tell. I noticed nary a slowdown, and was never left wanting more. The processor handled anything I threw at it, whether it be HD video or some severe multitasking. And combined with 1 GB of DDR2 RAM, the Atrix 2 is a powerhouse. Also under the hood is a radio capable of handling AT& T's HSPA 2. Aside from sheer processing power, the Atrix 2 screams thanks to the network's “true 4. G” speeds. Let me preface this by saying that AT& T needs to get its act together. This 4. G falls somewhere between the measly speeds we saw on the Atrix 4. G and the mind- blowing speed we see on AT& T's LTE network. Technically what we've got here isn't the fastest out there, but it certainly gets the job done. It's noticeably snappier than AT& T's 3. G speeds but if you're looking for broadband replacement ala Verizon, you're out of luck, especially so if you're in a less- than- stellar coverage zone. Here in New York City I saw average speeds of 3 Mbps down and 1. Mbps up, with the high end topping out at around 6 Mbps down and 1. Mbps up. When I visited family back home in Northeastern Pennsylania, I managed to crack 8. Mbps down and 1. 7 Mbps up. Depending on what you're looking for, you might want to give it a spin in your local AT& T store to see if your area supports the speeds you need. Supplying power to all these hungry components is a 1,7. Ah battery that produced pretty respectable wake times. I never found myself frantically looking for a plug, which is really refreshing lately. It's not the best in the biz, and you're going to want to keep a spare/charger handy if you'll be away for more than about 1. But with careful use, I easily got through the majority of the day on a single charge. Some other odds and ends. UMTS 8. 50/1. 90. GSM 8. 50/9. 00/1. Internal memory: 8 GB ROM, 1 GB RAM, 2 GB micro. SD. The Atrix 2 is running Android 2. Gingerbread underneath Motorola's evolving and, dare I say usable, custom skin. Have you ever used Android? Then you know what using the Atrix 2 is like. It's great to see that Motorola managed to ship with the absolute latest version of Gingerbread, but you know what's not so great? No Ice Cream Sandwich. I would imagine that the Atrix 2 is lined up for the upgrade in due time, but just be aware that if you commit to two years for an Atrix 2, some of your friends might get ICS before you. Bummer. And about that custom skin: it's a work in progress, and gets better with each new device. It is absolutely identical to what we saw on the Bionic and the Droid X2, but performance is noticeably better than the latter. Things are snappy: apps open without hesitation, and multitasking is a breeze. Bootup time is notceably quick, too. Is this due to the Atrix's heavy- duty processor? But I'm willing to bet that Motorola has been working dilligently on improving performance. Whereas the X2 lagged even when being pushing along by its dual- core processor, the Atrix 2 chews through tasks. Motorola is doing some heavy duty tinkering. Preinstalled are all of AT& T's usual suspects, including its Live TV, Music Store, and Yellow Pages, among others. And let us not forget Zumo. Cast, Motorola's file- sharing software that is just tops. It really works great. You'll need to create an account, and download Zumo. Cast to your PC or Mac. Once set up, you cans stream photos, videos, and music from your home computer to your Atrix 2. And even cooler is that Motorola seems to be committed to Zumo. Cast and including it in many if not all new devices. And one more thing about those 4. G speeds: they are certainly high enough to handle the challenges of using Mobile Hotspot. I saw little latency when running my computer, Wii, and tablet all off of the Atrix 2. Not saying that's something you would want to due (AT& T's data prices might make you think twice about it), but it's good to know that it's possible. MP and 1. 08. 0p recording. A camera is only as good as how quickly and easily you can capture the subject. In the past Motorola cameras have been slow to focus, slow to shoot, and downright aggrevating in terms of quality. The Atrix 2 is a step in the right direction, but Motorola isn't quite there yet. I'd like to dispute Motorola's claims of having shutter and start up speeds equal to real digital cameras. They're faster than what we've seen on the Droid line and even the Bionic, but the Atrix 2's camera is not my favorite. I've seen much better photo quality both Samsung and HTC hardware, and those cameras have faster start- up times and more user- friendly interfaces. It gets the job done, but again, it certainly lags behind its Samsung and HTC competition. Lap. Dock. From what I can tell, Motorola is looking to create a niche for itself in the smartphone market with its Webtop capabilities. My advice to Motorola: big mistake. Let me try to put this as concisely and nicely as I can: the Lap. Dock that Motorola wants you to shell over $2. It's slow, it's awkard, and the software is still so far from primetime. At this point I doubt that the hardware Motorlola is including inside its smartphones is enough to handle the demands of the Lap. Dock. Web browing is crazy slow, and don't even bother trying to do much else with it. Sure, it's good for taking notes or writing up the occasional word doc, but its frustratingly slow. It can't replace your laptop, or your tablet, or even your pen and paper at this point, so I really don't see how you can justify the price. Sorry Motorola, but keep trying. I appreciate the effort and I truly think it's a great idea that will set Moto apart from the pack, but it really needs some more time. For $9. 9 on contract you have to be willing to make some concessions. No, the Atrix 2 doesn't have the fastest processor or the highest- res screen or the next- gen version of Android. But what it does have is respectable specs for an attractive price. You're getting a solid device, one that benefits from a super fast processor and a close- to- optimized manufacturer skin. You're getting a gorgeous display atop a lightweight (albeit plasiticky) frame. Sure, I wish the camera was on par with the rest of the industry, and I wish that Motorola would stop placing all of its bets on the Lap. Dock, but for $9. Atrix 2 is hard to beat. If you've got a slightly higher budget you'd be a fool to pass up the Galaxy S II or any of the next- gen HTC devices (or even Moto's next batch, including the RAZR). But let your wallet make this decision. Prosoniq Orange Vocoder . Compatible with Power. PC Macs only, not Intel- Mac capable. Now for RTAS! With a fully- customizable realistic analog sounding vocoder effect and an 8- voice analog synthesizer aboard, the Orange Vocoder is the ideal tool for voice effects, triggering pad sounds with rhythmic phrases, or morphing between two audio signals! It's also a great creative tool, letting you alter and manipulate drum loops for totally new sounds. Prosoniq Orange Vocoder Features: Integrated 8- voice virtual analog synthesizer with 2 oscillators per voice featuring 1. 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I was hoping to be able to play my keyboard and talk into my mic while streaming it through Pro Tools to. Upgrading to Windows 10!!? 8 answers I got a 32GB USB with my. Lots of great presets! How To Fix Installshield Error 1. Manually editing the Windows registry to remove invalid Error 1. PC service professional. Incorrectly editing your registry can stop your PC from functioning and create irreversible damage to your operating system. In fact, one misplaced comma can prevent your PC from booting entirely! Because of this risk, we highly recommend using a trusted registry cleaner such as Win. Error 1607 problems include computer crashes, freezes, and possible virus infection. Learn how to fix these Installshield runtime errors quickly and easily! Error -1607: Unable to Install InstallShield Scripting Runtime 1607: Unable to install InstallShield Scripting Runtime. Software & Operating Systems. Microsoft, Linux, Productivity software, discussion. Unable to install InstallShield Scripting Runtime. Posted by cyclone3211. Thruster (Developed by Microsoft Gold Certified Partner) to scan and repair any Error 1. Using a registry cleaner automates the process of finding invalid registry entries, missing file references (like the one causing your 1. A backup is automatically created before each scan, with the ability to undo any changes in a single click, protecting you against the possibility of PC damage. The best part is that repairing registry errors can also dramatically improve system speed and performance. Caution: Unless you an advanced PC user, we DO NOT recommend editing the Windows registry manually. Using Registry Editor incorrectly can cause serious problems that may require you to reinstall Windows. We do not guarantee that problems resulting from the incorrect use of Registry Editor can be solved. Use Registry Editor at your own risk. To manually repair your Windows registry, first you need to create a backup by exporting a portion of the registry related to Error 1. Installshield): Click the Start button. Type . DO NOT hit ENTER yet! While holding CTRL- Shift on your keyboard, hit ENTER. You will be prompted with a permission dialog box. Click Yes. A black box will open with a blinking cursor. Type . Installshield) you want to back up. From the File menu, choose Export. In the Save In list, select the folder where you want to save the Installshield backup key. In the File Name box, type a name for your backup file, such as . Problem: During installation, I receive 'Error -1607: Unable to install InstallShield Scripting Runtime'. Solution: This is not a Documents To Go error. It is an InstallShield error code which indicates a problem with the. To resolve this problem, use one of the following methods: Reinstall the InstallScript engine To reinstall the InstallScript engine from InstallShield Developer, follow these steps: Download the IsScript7.zip file. 1607:Unable to install InstallShield Scripting Runtime. This technote explains why the error, 'Unable to install InstallShield Scripting Runtime,' occurs when trying to install IBM Rational version 2003.06 products on Microsoft Windows. 1607: Unable to install InstallShield Scripting Runtime. I downloaded these updates and when I try to run them I get the InstallShield runtime issue. DELL.COM > Community > Support Forums > Software & Operating Systems. How to Resolve InstallShield Error 1607: Unable to Install InstallShield Scripting Run Time. Last Update: 26 June 2008 Product: StarSQL Version: 5.x Article ID: SQV00SQ012. Using a 'Basic MSI Project' with a few InstalScript backed Custom Actions, I get a clean compile and build, but when I try a 'Test' run (hit CTRL-T), i get the error 1607 dialog noted in the subject line. If you would like to learn more about manual registry editing, please see the links below. We do not claim any responsibility for the results of the actions taken from the content linked below - complete these tasks at your own risk. Windows XPhttp: //www. Unable to install Install. Shield Scripting Runtime. We get the following dialog from our install cd when we install on some of our machines. I looked on the install cd and it's there in plain sight as a separate program. How do I go about running this program? |
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